The Effect Of Chronic Anaerobic Exercise On Blood Nesfatin-1 Levels And The Role Of Nesfatin-1 rs757081 C>G Polymophism
Project no. 23061 · Status: Kapanmış (Yayın bekleniyor) · 2021
Summary
<p>The rate of obesity is increasing in the world and in our country. Nesfatin-1 is an appetite regulating neuropeptide hormone that is widely expressed in stomach and adipose tissue. The role of Nesfatin-1 in the regulation of insulin secretion, glucose homeostasis and energy balance and its relationship with obesity are known. Aerobic exercise is known to improve (increase) Nesfatin-1 levels. However, the role of Nesfatin-1 rs757081 C>G polymorphism (NP), which is known to cause individual differences in the release of this hormone, on these effects of exercise is still unclear. It is also stated that Nesfatin-1 is associated with nitric oxide (NO) in rats. NO, which is known to have a role in the insulin-independent entry of glucose into the cell, may have a synergistic positive effect on blood glucose concentration with Nesfatin-1 through exercise. However, this is unknown. In addition, the effects of anaerobic exercises performed by many athletes in the world on Nesfatin-1 and NO are not clear. The negative effect of oxidative stress on both Nesfatin-1 and NO is known. Therefore, a chronic anaerobic training is likely to have a negative effect on these two parameters. However, this is not clear.</p><p>For these reasons; In this study, the effects of chronic anaerobic training on serum Nesfatin-1, NO, glucose and insulin levels will be determined in healthy male adult athletes (n=40-50) doing anaerobic sports and sedentary people (n=40-50) with similar physical characteristics. In addition, the effects of these trainings on some indicators of inflammation and oxidative stress that may be associated with Nesfatin-1 and NO, and the role of NP in all these possible effects will be investigated. NP will be determined from genomic DNA samples. As far as we know, the phenotypic responses (changes) of the investigated parameters to an anaerobic type of exercise will be the first in the literature. In addition, the results of the study may contribute to the preparation of healthier and more modern training programs for athletes according to their phenotypes.</p>