Investigation of ACE Gene Indel Polymorphism Frequency in Alzheimer'S Patients
Project no. 21806 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss and progressive neurocognitive dysfunction. It was introduced in 1906 by Alois Alzheimer. By the development of genome-wide association studies (GWAS) and next-generation sequencing, many genetic risk factors for Alzheimer's disease have been identified. The association of angiotensin converting enzyme gene (ACE) insertion/deletion (I/D or indel) polymorphism with Alzheimer's disease (AD) has been revealed in different studies. The aim of this study was to determine whether ACE indel polymorphism is associated with Alzheimer's disease risk in individuals who applied to the Neurology Clinic of İzmir Çiğli Training and Research Hospital and were diagnosed with Alzheimer's disease. For this purpose, genotype and allele frequencies of ACE I/D gene polymorphism in 50 patients and 50 control individuals were analyzed and compared. No significant difference was detected in DD (p=0.886), ID (p=0.516) and II (p=0.165) genotypes and D (p=0.606) and I (p=0.453) alleles between the patient and control groups. Therefore no association was determined between AD and ACE indel polymorphism in the studied population. In order for the ACE indel polymorphism to be used as a biomarker for AD, it is very important to understand the relationship between ACE and the disease. It is recommended to study with more samples to be obtained from different regions of Turkey in future studies.