NEUROIMAGING FINDINGS OF THE CASES WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER AND SLUGGISH COGNITIVE TEMPO
Project no. 36 · Status: Kapanmış · 2016
Summary
Introduction: Attention Deficit and Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in school-age children worldwide with 3-5% prevalence (Polanczyk et al., 2015). SCT (Sluggish Cognitive Tempo); it is a cognitive arousal and vigilance disorder showing clinical signs such as daydreaming, difficulty in being awake, low energy, living in its own world, being confused. Although SCT was previously thought to be a subtype of ADHD, recent research has shown a distinct disorder. Objective: The aim of this study was to compare the findings of diffusion tensor imaging (DTI), arterial spin labeling (ASL) and functional MRI (fMRI) with SCT and comorbid ADHD. In our study, 18 SCT-ADHD-Combined Type (ADHD-CT) and 24 SCT-ADHD-Inattentive Type (ADHD-IA) cases were compared with 24 healthy controls. Results: In terms of diffusion tensor imaging findings, a statistically significant increase in FA was found in the SCT comorbid ADHD-IA cases, including cerebral peduncle, internal capsule and right fornix (P <0.05). When a task requiring attention was given to SCT cases, posterior brain regions (Occipital Zone, Angular Girus, Lateral Occipital Cortex superior and inferior divisions) were more active during fMRI (P <0.05). Arterial Spin Labelling showed a significant statistical difference in all SCT cases between basal and activated states of Lingual gyrus, occipital fusiform gyrus, precuneus, posterior cingulat gyrus. Discussion: This study is the first study to compare the results of diffusion tensor imaging and Arterial Spin Labeling with the healthy control group of SCT comorbid ADHD patients. The high incidence of SCT comorbidity in ADHD patients may have an impact on inconsistent results obtained in ADHD and neuroimaging studies.