Investigation of the Effects of the Use of Antioxidant and Lipid Peroxidation Inhibitors on Recovery in an Experimental Spinal Cord Injury Model
Project no. 23305 · Status: Kapanmış (Yayın bekleniyor) · 2021
Summary
<p>One of the most valid mechanisms of "secondary damage" uncovered in SCI (Spinal Cord Injury) studies is lipid peroxidation (LP) damage caused by oxygen radicals. Increased reactive free radicals (i.e., "oxidative stress") in the damaged brain or spinal cord have been shown to cause "oxidative damage" to cellular lipids and proteins, which will lead to functional cell death in both the microvascular dimension and the brain parenchymal.</p><p><br></p><p>The main form of oxidative damage caused by free radicals occurs when polyunsaturated fatty acids in cell membranes trigger the lipid peroxidation (LP) process.</p><p><br></p><p>Ferroptotic cell death contributes to secondary damage in spinal cord injuries It is predicted that ferroptotic cell death is a key pathway in acute neuronal damage and will shape the future direction of treatment efforts in this regard. Spinal cord injury has also started to be studied under this heading up-to-date; although the presence of ferroptosis has been confirmed in spinal cord injuries</p>