EVALUATION OF CONJUNCTIVAL CHANGES WITH IMPRESSION CYTOLOGY IN PATIENTS USING VORICONAZOL DROP
Project no. 143 · Status: Kapanmış · 2018
Summary
Voriconazole is a broad spectrum antifungal drug which causes squamous cell neoplasia in patients taking systemic medication. There are also some animal studies suggesting that ocular surface squamous cell neoplasms can be triggered in topical use. The aim of this study was to evaluate the results of conjunctival impression cytology in order to reveal possible ocular surface changes in patients using voriconazole drops due to fungal keratitis. Thirty eyes of 30 patients who received 1% voriconazole drops for fungal keratitis were included as study group and healthy fellow eyes of the patients included as control group. Membrane filter paper was placed on the superior, inferior, nasal and temporal quadrants of the bulbar conjunctiva under topical anesthesia for 10 seconds. The specimen taken away from the conjunctiva and fixed with alcohol to score cytologically according to the Nelson classification. The mean age of the patients was 67.55±20.35 (14-85) years. The mean age of the patients was 63.41 ± 18.53 (33-85) years. The mean duration of drug use was 189.19 ± 105.20 (15-420 days). The mean scores in study group eyes were 1.21 ± 0.92 (0-3) in the superior, 1.63 ± 0.63 (0-2) in the inferior, 1.61 ± 0.89 (1-3) in the nasal and 1,54±0,85 (1-3) in the temporal. The mean scores of the fellow eyes of the patients were 0.89 ± 0.68 (0-2) in the superior, 1.12 ± 0.85 (0-2) in the inferior, 1.16 ± 0.83 (0-2) in the nasal, temporally, it was 1.29 ± 0.97 (0-2). Although the scores obtained in the patients' eyes were higher in the comparisons, there was no statistically significant difference (p was 0.411 in the superior, 0.111 in the inferior, 0.60 in the nasal and 0.28 in the temporal). In this study, it was shown that some cytological changes occurred in the ocular surface after the use of voriconazole drops in the human eye, although these were not statistically significant. Further studies with larger groups of patients are needed to elaborate these changes.