Preparation and Characterisation of Polymer Film Electrode and Application to medicinal tablets for Atenolol determination
Project no. 475 · Status: Kapanmış · 2017
Summary
Zinc oxide nanoparticles doped graphene oxide modified glassy carbon electrodes (Zn-GO/GCE) were fabricated and were used for sensitive and selective differential pulse voltammetric (DPV) detection of atenolol (ATE). The morphological and chemical characterizations of modified electrodes were carried out with electron diffraction spectroscopy (EDS), scanning electron microscopy (SEM) and X-Ray photoelectron spectroscopy (XPS). The amounts of the electrode modifiers and the DPV parameters were optimized. It was found that the electrode modified with 1.0 mmol L-1 ZnSO4, -1.3 V of electodeposition potential, 120 seconds of electrodeposition time exhibited the best analytical response towards the determination of ATE by cyclic voltammetry (CV). The DPV parameters which are pulse amplitude, scan rate and modulation time were optimized as 50 mV, 5 mV s-1 and 7 ms, respectively. The calibration curves of ATE were obtained at Zn-GO/GCE using DPV technique with two different linear parts: 7.8 - 84 µmol L-1 and 167 µmol L-1 - 639 µmol L-1. The detection limit (LOD) was also calculated as 2.5 µmol L-1. The fabricated electrode in this study is selective for ATE in the presence of some electroactive molecules. The sensitive, selective, accurate and cheap modified electrode also utilized for the detection of ATE in atenolol medicine tablets with good recovery.