Role of Apocynin in Preventing Intestinal Ischemia Reperfusion Injury in Rats
Project no. 26322 · Status: Kapanmış (Yayın bekleniyor) · 2023
Summary
<p>Ischemia is defined as a number of changes that occur as a result of insufficient blood flow to the tissues and the resulting cell damage and organ failure. In order to prevent this, adequate blood flow and oxygen must be provided to the tissues. However, the return of oxygenated blood to ischemic tissue paradoxically initiates a reaction process that further damages the tissue. Ischemia reperfusion injury is the irreversible increase of toxic metabolites accumulated in the tissues with ischemia and the damage to the cells caused by a series of cellular and humoral events that develop after reperfusion. Free oxygen radicals (ROS) formed from oxygen coming into the tissues especially after reperfusion play an important role in this process. ROS are also formed in normal cells and damage is prevented by stabilizing mechanisms. However, toxic metabolites accumulated in ischemia and decreased antioxidant enzyme systems cause reperfusion injury after ischemia. Apocynin inhibits NADPH oxidase, the enzyme responsible for the formation of free oxygen radicals. The efficacy of apocynin in pathologies in organs such as nervous system, vascular system, kidney, liver, pancreas has been experimentally proven in different previous studies. In this study, in which the efficacy of apocynin in intestinal ischemia reperfusion injury was examined by histological, immunohistochemical and biochemical methods for the first time, if the data to be obtained from further investigations support our hypothesis, other studies will be conducted.</p>