Development of a Magnetic Hyperthermia System and Its application of Image-Guided Anti-Collagenase Antibody Conjugated FDG mNPs in Cancer Cell Magnetic Hyperthermia.
Project no. 22108 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
<p>This research project aims to assess the potential utility of FDG-mNPs (Fluorodeoxyglucose-loaded magnetic nanoparticles) and anti-collagenase antibody conjugates through a established magnetic hyperthermia system, with a focus on their prospective application in clinical cancer treatment. The scope of the project encompasses (i) the development of modified FDG-mNP particles that can be effectively applied in cancer hyperthermia, (ii) investigation of the in vitro cytotoxicity and hyperthermic activities of FDG-mNPs in a cancer cell culture environment, and (iii) the ultimate development of a suitable magnetic induction heating system for use in applications.</p><p>The research project has facilitated the development of magnetic particles and a magnetic heating system for magnetic hyperthermia applications, thereby establishing infrastructure in this field at our university. The knowledge and expertise acquired through the infrastructure established within the scope of the project will be utilized in in vivo applications of magnetic hyperthermia. These applications will focus on investigating the safety of magnetic nanoparticles (mNPs) and anti-collagenase antibody conjugates, as well as exploring their potential in cancer treatment. This will enable our university to create an interdisciplinary platform for preclinical studies and research in the field of magnetic hyperthermia applications, particularly in the context of cancer treatment.</p><p>Magnetic hyperthermia represents a novel approach to cancer treatment, creating a multidisciplinary work environment that can bring together medicine, technology, and industry. The infrastructure developed at our university is poised to serve as a valuable resource for advancing interdisciplinary research and preclinical investigations in magnetic hyperthermia applications.</p><p>The knowledge and experience acquired through the university-industry collaboration within the scope of the project will create new opportunities, particularly in the development of novel magnetic hyperthermia systems for oncological treatment and the transformation of these innovations into economically valuable products. The project has successfully fulfilled the requirements of our university for both chemical and electronic infrastructure essential for preclinical medical applications of magnetic hyperthermia. This accomplishment sets the stage for the exploration of new avenues in research and development, with the potential to contribute to the creation of economically viable products targeting oncological therapies.</p>