The Relationship Between Maresin-1 and Inflammatory Processes in Patients with Acute Stroke
Project no. 32075 · Status: Kapanmış (Yayın bekleniyor) · 2024
Summary
<p><strong>The Relationship Between Maresin-1 and Inflammatory Processes in Patients with Acute Stroke</strong></p><p><strong>Introduction and Objectives: </strong>Stroke is the second leading cause of death worldwide, and the treatment of disabilities after stroke has a significant share in health expenditures, especially in developing countries. Inflammation is considered as a factor involved both in etiology and pathogenesis of stroke. In this study, we aimed to determine the levels of maresin 1, which antiinflammatory and inflammation resolution effetcts have been demonstrated in experimental and <em>in vitro</em> studies, and explore its relationship with other inflammatory markers in acute ischemic stroke.</p><p><strong>Materials and Methods: </strong>This prospective study included 58 patients with acute ischemic stroke and 30 healthy volunteers, without any health problems according to history and physical examination, as the control group. Sociodemographic characteristics and smoking status of all participants were recorded In addition, for the patient group, information on stroke-related risk factors, use of anti-aggregants, stroke location, presence of thrombectomy and stroke intensity were recorded. Venous blood samples collected from all the participants were centrifuged, and sera were freezed at -80° C until analysis. Maresin-1 levels were measured by an ELISA, lipoprotein-associated phospholipase A2 levels were determined by an automated chemiluminescence, finally serum amyloid A and C-reactive protein levels were measured by automated nephelometric and turbidimetric methods, respectively,</p><p><strong>Results:</strong> In this study, maresin-1 levels of the stroke group were less then the control group (1229.78±215.65 pg/mL vs. 1310.91±148.68 pg/mL). CRP and serum amyloid A levels were increased in the ischemic stroke group, whereas lipoprotein-associated phospholipase A2 levels were indifferent. Maresin-1 and CRP levels were found to be positively correlated in the patient group (rho=0,281, p=0,033).</p><p><strong>Conclusion:</strong> Maresin-1, exerting antiinflammatory and resolutive effects, concentrations decrease and systemic inflammatory markers increase in acute ischemic stroke. In this study, we demonstrated the important role of inflammatory processes in clinical ischemic stroke settings. Our results suggest that in ischemic stroke maresin-1 is depleted. This study is one of the very few studies conducted in clinical settings, therefore further studies including more participants are needed to verify our results.</p><p><strong>Keywords: </strong>Stroke, ischemic stroke, inflammation, resolution, maresin-1</p>