Investigation of the Prevalence of von Willebrand Disease in Women with Abnormal Uterine Bleeding

Project no. 33054 · Status: Kapanmış (Yayın bekleniyor) · 2025

Summary

<p>Abnormal&nbsp;uterine&nbsp;bleeding&nbsp;(AUB)&nbsp;is&nbsp;a&nbsp;common&nbsp;gynecological&nbsp;problem&nbsp;that&nbsp;adversely&nbsp;affects&nbsp;the&nbsp;quality&nbsp;of&nbsp;life&nbsp;of&nbsp;women&nbsp;of&nbsp;reproductive&nbsp;age.&nbsp;The&nbsp;aim&nbsp;of&nbsp;this&nbsp;study&nbsp;is&nbsp;to&nbsp;determine&nbsp;the&nbsp;prevalence&nbsp;of&nbsp;von&nbsp;Willebrand&nbsp;disease&nbsp;(vWD)&nbsp;among&nbsp;women&nbsp;presenting&nbsp;with&nbsp;AUB&nbsp;and&nbsp;to&nbsp;assess&nbsp;bleeding&nbsp;tendency&nbsp;using&nbsp;the&nbsp;ISTH&nbsp;Bleeding&nbsp;Assessment&nbsp;Tool&nbsp;(ISTH-BAT)&nbsp;and&nbsp;the&nbsp;Pictorial&nbsp;Bleeding&nbsp;Assessment&nbsp;Chart&nbsp;(PBAC).&nbsp;The&nbsp;study&nbsp;will&nbsp;be&nbsp;conducted&nbsp;at&nbsp;the&nbsp;General&nbsp;Internal&nbsp;Medicine&nbsp;Outpatient&nbsp;Clinic&nbsp;of&nbsp;the&nbsp;Department&nbsp;of&nbsp;Internal&nbsp;Medicine&nbsp;and&nbsp;the&nbsp;Division&nbsp;of&nbsp;Hematology,&nbsp;Ege&nbsp;University&nbsp;Faculty&nbsp;of&nbsp;Medicine&nbsp;Hospital,&nbsp;and&nbsp;is&nbsp;planned&nbsp;as&nbsp;a&nbsp;prospective,&nbsp;cross-sectional,&nbsp;analytical&nbsp;study.&nbsp;A&nbsp;total&nbsp;of&nbsp;110&nbsp;female&nbsp;volunteers&nbsp;selected&nbsp;using&nbsp;purposive&nbsp;sampling&nbsp;will&nbsp;be&nbsp;included&nbsp;in&nbsp;the&nbsp;study.&nbsp;The&nbsp;inclusion&nbsp;criteria&nbsp;will&nbsp;comprise&nbsp;female&nbsp;patients&nbsp;aged&nbsp;18–45&nbsp;years,&nbsp;while&nbsp;patients&nbsp;with&nbsp;abnormal&nbsp;uterine&nbsp;bleeding&nbsp;due&nbsp;to&nbsp;organic&nbsp;causes&nbsp;and&nbsp;those&nbsp;with&nbsp;a&nbsp;known&nbsp;diagnosis&nbsp;of&nbsp;a&nbsp;bleeding&nbsp;disorder&nbsp;will&nbsp;be&nbsp;excluded.&nbsp;Demographic&nbsp;characteristics,&nbsp;clinical&nbsp;histories,&nbsp;ISTH-BAT&nbsp;scores,&nbsp;and&nbsp;PBAC&nbsp;scores&nbsp;will&nbsp;be&nbsp;recorded.&nbsp;Laboratory&nbsp;investigations&nbsp;will&nbsp;include&nbsp;complete&nbsp;blood&nbsp;count,&nbsp;activated&nbsp;partial&nbsp;thromboplastin&nbsp;time&nbsp;(aPTT),&nbsp;prothrombin&nbsp;time&nbsp;(PT),&nbsp;fibrinogen,&nbsp;von&nbsp;Willebrand&nbsp;factor&nbsp;(vWF)&nbsp;antigen&nbsp;and&nbsp;ristocetin&nbsp;cofactor&nbsp;activity,&nbsp;factor&nbsp;VIII,&nbsp;ferritin,&nbsp;and&nbsp;PFA-100.&nbsp;Data&nbsp;will&nbsp;be&nbsp;analyzed&nbsp;using&nbsp;SPSS&nbsp;version&nbsp;24,&nbsp;and&nbsp;a&nbsp;p-value&nbsp;&lt;0.05&nbsp;will&nbsp;be&nbsp;considered&nbsp;statistically&nbsp;significant.&nbsp;This&nbsp;study&nbsp;will&nbsp;be&nbsp;one&nbsp;of&nbsp;the&nbsp;studies&nbsp;investigating&nbsp;the&nbsp;prevalence&nbsp;of&nbsp;vWD&nbsp;in&nbsp;a&nbsp;large&nbsp;sample&nbsp;of&nbsp;patients&nbsp;with&nbsp;AUB&nbsp;in&nbsp;Türkiye&nbsp;and&nbsp;is&nbsp;expected&nbsp;to&nbsp;contribute&nbsp;to&nbsp;the&nbsp;clinical&nbsp;evaluation&nbsp;of&nbsp;patients&nbsp;with&nbsp;AUB&nbsp;and&nbsp;facilitate&nbsp;the&nbsp;development&nbsp;of&nbsp;diagnostic&nbsp;algorithms.</p>

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