Synthesis of Some Potentially Active Heterocyclic Compounds
Project no. 251 · Status: Kapanmış · 2016
Summary
Although myeloperoxidase is an enzyme with an important supporting role on human immune system through the formation of strong oxidative products, it is also known that these products can cause tissue damage by oxidation of biomolecules which lead to inflammatory syndromes. Therefore, MPO has recently become a remarkable therapeutic target. In this study, benzimidazole derivatives were designed and synthesized as potential MPO inhibitors.