SYNTHESIS AND CHARACTERIZATION OF THYMOQUINONE-LOADED NANOPARTICLES

Project no. 29594 · Status: Kapanmış (Yayın bekleniyor) · 2023

Summary

<p class="ql-align-justify"> Cancer&nbsp;is&nbsp;the&nbsp;second&nbsp;most&nbsp;common&nbsp;cause&nbsp;of&nbsp;death&nbsp;worldwide&nbsp;after&nbsp;cardiovascular&nbsp;diseases.&nbsp;Chemotherapy&nbsp;is&nbsp;a&nbsp;widely&nbsp;used&nbsp;treatment&nbsp;method,&nbsp;but&nbsp;serious&nbsp;side&nbsp;effects&nbsp;can&nbsp;limit&nbsp;its&nbsp;effectiveness.&nbsp;Natural&nbsp;compounds,&nbsp;due&nbsp;to&nbsp;their&nbsp;low&nbsp;toxicity&nbsp;and&nbsp;diverse&nbsp;mechanisms&nbsp;of&nbsp;action,&nbsp;hold&nbsp;significant&nbsp;potential&nbsp;as&nbsp;alternative&nbsp;treatment&nbsp;options.&nbsp;Drug&nbsp;delivery&nbsp;systems&nbsp;are&nbsp;becoming&nbsp;increasingly&nbsp;important&nbsp;to&nbsp;enhance&nbsp;the&nbsp;therapeutic&nbsp;efficacy&nbsp;of&nbsp;these&nbsp;compounds.&nbsp;Thymoquinone&nbsp;(TQ)&nbsp;is&nbsp;a&nbsp;natural&nbsp;compound&nbsp;found&nbsp;in&nbsp;<em>Nigella&nbsp;sativa</em>&nbsp;with&nbsp;notable&nbsp;anticancer&nbsp;properties.&nbsp;However,&nbsp;its&nbsp;bioavailability&nbsp;is&nbsp;limited&nbsp;due&nbsp;to&nbsp;its&nbsp;poor&nbsp;solubility&nbsp;in&nbsp;water.&nbsp;In&nbsp;this&nbsp;study,&nbsp;the&nbsp;aim&nbsp;was&nbsp;to&nbsp;enhance&nbsp;the&nbsp;therapeutic&nbsp;efficacy&nbsp;of&nbsp;thymoquinone&nbsp;for&nbsp;use&nbsp;in&nbsp;the&nbsp;treatment&nbsp;of&nbsp;various&nbsp;cancer&nbsp;types&nbsp;and&nbsp;to&nbsp;achieve&nbsp;an&nbsp;effective&nbsp;and&nbsp;safe&nbsp;therapy&nbsp;at&nbsp;low&nbsp;doses.&nbsp;Accordingly,&nbsp;thymoquinone-loaded,&nbsp;alginate-coated&nbsp;PLGA&nbsp;(poly&nbsp;D,&nbsp;L-lactic-co-glycolic&nbsp;acid)&nbsp;nanoparticles&nbsp;were&nbsp;prepared&nbsp;using&nbsp;the&nbsp;nanoprecipitation&nbsp;method.&nbsp;Prepared&nbsp;nanoparticles&nbsp;were&nbsp;analyzed&nbsp;by&nbsp;HPLC&nbsp;method;&nbsp;encapsulation&nbsp;efficiency&nbsp;and&nbsp;drug&nbsp;release&nbsp;profile&nbsp;were&nbsp;investigated.&nbsp;Additionally,&nbsp;their&nbsp;chemical&nbsp;structure,&nbsp;morphology,&nbsp;and&nbsp;particle&nbsp;characteristics&nbsp;were&nbsp;characterized&nbsp;through&nbsp;FTIR,&nbsp;SEM,&nbsp;and&nbsp;TEM&nbsp;analyses.</p><p class="ql-align-justify"> &nbsp;The&nbsp;findings&nbsp;show&nbsp;that&nbsp;the&nbsp;developed&nbsp;nanoparticles&nbsp;can&nbsp;potentially&nbsp;increase&nbsp;the&nbsp;bioavailability&nbsp;of&nbsp;thymoquinone&nbsp;by&nbsp;providing&nbsp;controlled&nbsp;release&nbsp;and&nbsp;can&nbsp;be&nbsp;a&nbsp;promising&nbsp;drug&nbsp;delivery&nbsp;system&nbsp;in&nbsp;cancer&nbsp;treatment.</p><p></p>

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