Investigation of some nonsteroidal anti-inflammatory drugs (NSAIDs) in the water and sediment of Izmir Bay

Project no. 32330 · Status: Kapanmış (Yayın bekleniyor) · 2024

Summary

<p class="ql-align-center"><strong style="color: black;">ABSTRACT</strong></p><p><span style="color: black;">Gulfs,&nbsp;compared&nbsp;to&nbsp;the&nbsp;open&nbsp;sea,&nbsp;are&nbsp;among&nbsp;the&nbsp;marine&nbsp;environments&nbsp;most&nbsp;affected&nbsp;by&nbsp;pollution&nbsp;due&nbsp;to&nbsp;their&nbsp;low&nbsp;water&nbsp;movement,&nbsp;shallow&nbsp;depths,&nbsp;and&nbsp;dense&nbsp;human&nbsp;populations.&nbsp;The&nbsp;Inner&nbsp;Gulf&nbsp;of&nbsp;Izmir&nbsp;has&nbsp;been&nbsp;under&nbsp;pressure&nbsp;from&nbsp;many&nbsp;pollutants&nbsp;for&nbsp;the&nbsp;last&nbsp;60&nbsp;years.&nbsp;Among&nbsp;these&nbsp;pollutants,&nbsp;some&nbsp;commonly&nbsp;used&nbsp;non-steroidal&nbsp;anti-inflammatory&nbsp;drugs&nbsp;(NSAIDs)&nbsp;are&nbsp;particularly&nbsp;noteworthy.&nbsp;The&nbsp;aim&nbsp;of&nbsp;this&nbsp;study&nbsp;is&nbsp;to&nbsp;investigate&nbsp;some&nbsp;NSAIDs&nbsp;(ibuprofen,&nbsp;dichlorophenac,&nbsp;naproxen,&nbsp;and&nbsp;acetylsalicylic&nbsp;acid)&nbsp;that&nbsp;have&nbsp;not&nbsp;been&nbsp;studied&nbsp;before&nbsp;in&nbsp;the&nbsp;Inner&nbsp;Gulf&nbsp;of&nbsp;Izmir.&nbsp;For&nbsp;this&nbsp;purpose,&nbsp;samples&nbsp;were&nbsp;taken&nbsp;from&nbsp;5&nbsp;stations&nbsp;in&nbsp;the&nbsp;Inner&nbsp;Gulf&nbsp;of&nbsp;Izmir&nbsp;and&nbsp;from&nbsp;the&nbsp;wastewater&nbsp;inlet&nbsp;and&nbsp;outlet&nbsp;of&nbsp;the&nbsp;Izmir&nbsp;Southwest&nbsp;Wastewater&nbsp;Treatment&nbsp;Plant.&nbsp;In&nbsp;addition,&nbsp;some&nbsp;physicochemical&nbsp;properties&nbsp;and&nbsp;nutrient&nbsp;concentrations&nbsp;of&nbsp;seawater&nbsp;were&nbsp;determined&nbsp;in&nbsp;the&nbsp;study.&nbsp;Naproxen&nbsp;was&nbsp;detected&nbsp;at&nbsp;all&nbsp;stations&nbsp;between&nbsp;232.5&nbsp;and&nbsp;2060.4&nbsp;ng/L.&nbsp;The&nbsp;lowest&nbsp;value&nbsp;was&nbsp;detected&nbsp;at&nbsp;Station&nbsp;5,&nbsp;which&nbsp;was&nbsp;selected&nbsp;as&nbsp;the&nbsp;reference&nbsp;station.&nbsp;In&nbsp;addition,&nbsp;dichlorophenac&nbsp;was&nbsp;measured&nbsp;at&nbsp;956.3&nbsp;ng/L&nbsp;at&nbsp;station&nbsp;1&nbsp;and&nbsp;1607.5&nbsp;ng/L&nbsp;at&nbsp;station&nbsp;3,&nbsp;indicating&nbsp;significant&nbsp;transport&nbsp;into&nbsp;the&nbsp;inner&nbsp;bay&nbsp;via&nbsp;small&nbsp;streams.&nbsp;At&nbsp;the&nbsp;treatment&nbsp;plant&nbsp;inlet,&nbsp;ibuprofen&nbsp;was&nbsp;detected&nbsp;at&nbsp;489.4&nbsp;ng/L,&nbsp;naproxen&nbsp;at&nbsp;6575.4&nbsp;ng/L,&nbsp;and&nbsp;dichlorophenac&nbsp;at&nbsp;1333.10&nbsp;ng/L.&nbsp;At&nbsp;the&nbsp;treatment&nbsp;plant&nbsp;outlet,&nbsp;the&nbsp;naproxen&nbsp;value&nbsp;(4528.6&nbsp;ng/L)&nbsp;decreased&nbsp;slightly.&nbsp;In&nbsp;this&nbsp;project,&nbsp;the&nbsp;first&nbsp;of&nbsp;its&nbsp;kind&nbsp;in&nbsp;the&nbsp;Izmir&nbsp;Bay,&nbsp;dichlorophenac&nbsp;and&nbsp;naproxen&nbsp;were&nbsp;predominantly&nbsp;detected.&nbsp;Regular&nbsp;monitoring&nbsp;studies&nbsp;at&nbsp;all&nbsp;levels&nbsp;of&nbsp;the&nbsp;ecosystem&nbsp;are&nbsp;crucial&nbsp;for&nbsp;a&nbsp;better&nbsp;understanding&nbsp;of&nbsp;the&nbsp;effects&nbsp;of&nbsp;these&nbsp;drugs&nbsp;in&nbsp;the&nbsp;Izmir&nbsp;Bay.</span></p><p></p><p><strong style="color: black;">Keywords:</strong><span style="color: black;">&nbsp;Nonsteroidal&nbsp;anti-inflammatory&nbsp;drugs&nbsp;(NSAIDs),&nbsp;naproxen,&nbsp;dichlorophenac,&nbsp;Izmir&nbsp;Inner&nbsp;Bay.</span></p>

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