SYNTHESIS OF NEW Pt AND Ru COMPLEXES AND DETERMINATION OF THEIR ANTI-ALZHEIMER PROPERTIES

Project no. 32365 · Status: Kapanmış (Yayın bekleniyor) · 2024

Summary

<p class="ql-align-justify">The&nbsp;final&nbsp;report&nbsp;of&nbsp;the&nbsp;General&nbsp;Research&nbsp;project&nbsp;consists&nbsp;of&nbsp;three&nbsp;sections.&nbsp;The&nbsp;first&nbsp;section&nbsp;includes&nbsp;literature&nbsp;data&nbsp;on&nbsp;Schiff&nbsp;bases&nbsp;and&nbsp;metal&nbsp;complexes&nbsp;synthesized&nbsp;with&nbsp;Schiff&nbsp;bases.&nbsp;This&nbsp;section&nbsp;also&nbsp;includes&nbsp;information&nbsp;on&nbsp;Alzheimer's&nbsp;disease.&nbsp;The&nbsp;second&nbsp;section&nbsp;contains&nbsp;the&nbsp;experimental&nbsp;section.&nbsp;This&nbsp;section&nbsp;includes&nbsp;the&nbsp;synthesis&nbsp;of&nbsp;two&nbsp;new&nbsp;ligands&nbsp;using&nbsp;4-ubiquinoline&nbsp;carboxyaldehyde&nbsp;and&nbsp;two&nbsp;different&nbsp;amines&nbsp;(o-phenylenediamine&nbsp;and&nbsp;5,5-dichlorophenylenediamine),&nbsp;and&nbsp;the&nbsp;synthesis&nbsp;of&nbsp;two&nbsp;new&nbsp;Pt&nbsp;complexes&nbsp;containing&nbsp;these&nbsp;ligands.&nbsp;The&nbsp;structures&nbsp;of&nbsp;the&nbsp;Pt(II)&nbsp;complexes&nbsp;(Complex&nbsp;I&nbsp;and&nbsp;Complex&nbsp;II)&nbsp;chelated&nbsp;with&nbsp;these&nbsp;Schiff&nbsp;bases&nbsp;were&nbsp;determined&nbsp;using&nbsp;elemental&nbsp;analysis,&nbsp;FT-IR,&nbsp;1H-NMR,&nbsp;and&nbsp;13C-NMR.&nbsp;The&nbsp;general&nbsp;structures&nbsp;of&nbsp;the&nbsp;complexes&nbsp;are&nbsp;shown&nbsp;below.</p><p class="ql-align-justify">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The&nbsp;synthesized&nbsp;compounds&nbsp;were&nbsp;determined&nbsp;to&nbsp;inhibit&nbsp;acetylcholinesterase,&nbsp;a&nbsp;key&nbsp;factor&nbsp;in&nbsp;Alzheimer's&nbsp;disease.&nbsp;The&nbsp;activity&nbsp;of&nbsp;the&nbsp;complexes&nbsp;on&nbsp;Aβ1-42,&nbsp;another&nbsp;Alzheimer's&nbsp;factor,&nbsp;was&nbsp;investigated&nbsp;using&nbsp;fluorescence&nbsp;measurements&nbsp;with&nbsp;Thioflavin&nbsp;T&nbsp;and&nbsp;AFM&nbsp;measurements.</p><p class="ql-align-justify"></p><p class="ql-align-justify">&nbsp;&nbsp;&nbsp;The&nbsp;third&nbsp;section&nbsp;evaluates&nbsp;and&nbsp;discusses&nbsp;the&nbsp;results&nbsp;of&nbsp;the&nbsp;studies,&nbsp;primarily&nbsp;focusing&nbsp;on&nbsp;the&nbsp;elucidation&nbsp;of&nbsp;the&nbsp;structures&nbsp;of&nbsp;Schiff&nbsp;bases&nbsp;and&nbsp;their&nbsp;Pt&nbsp;complexes&nbsp;using&nbsp;various&nbsp;spectroscopic&nbsp;methods&nbsp;and&nbsp;the&nbsp;evaluation&nbsp;of&nbsp;their&nbsp;biological&nbsp;studies.</p><p class="ql-align-justify"></p><p class="ql-align-justify"></p>

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