Investigation of Immunological Parameters in The First Episode Psychosis Patients After 6 Months From The Beginning Of The Treatment.
Project no. 20934 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
<p><strong>INTRODUCTION: </strong>Schizophrenia and related disorders are psychiatric diseases that progress with significant losses in social and professional fields. Current studies show that immunological processes play an important role in the occurrence of the disease. The purpose of this study is; to follow up the first episode psychosis (FEP) patients from the beginning of the treatment, to determine how the immunological markers of the patients change in the process and to investigate the relationship of this change with the severity of the symptoms.</p><p><strong>METHOD: </strong>Patients who previously participated in the study named "Investigation of Immunological Parameters in The First Episode Psychosis Patients" and who also volunteered to participate in this study were included. In order to observe the change in diagnosis, patients were invited to the second study at least 6 months after they were included in the first study. The follow-up was carried out prospectively. Positive and Negative Symptom Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS) were applied to determine symptom severity. To evaluate the change of immunological markers over time; the blood results of the patients who participated in the second study were compared with those of both patients and healthy controls who participated in the first study. In addition, the relationship between patients' symptom severity in this study and blood results in both this study and the first study were examined.</p><p><strong>RESULTS: </strong>20 of 32 patients who participated in the first study were included in this study. The leukocyte, neutrophil, monocyte, complement 3 and complement 4 levels and neutrophil / lymphocyte ratios of patients in both first time (T1) and second time (T2) are significantly higher than healthy controls. In terms of autoantibodies, there was no significant difference between the two groups. At the end of the follow-up, there was a significant decrease in PANSS positive, PANSS global, PANSS total and BPRS scores. According to the correlation analysis, it was found that there was a significant relationship between the immunoglobulin E (IgE) levels of the patients at T1 time and PANSS global, PANSS total and BPRS scores at T2 time.</p><p><strong>CONCLUSION: </strong>According to the results of this study; increased inflammatory activity was found in the first episode psychosis patients. Despite the decrease in the symptoms of the patients at the end of the follow-up period of approximately one year, this inflammatory activity persisted. There was no significant difference in terms of autoimmunity. </p>