Change of C-reactive protein (CRP), procalcitonin (PCT), leukocyte and lactate levels in experimental sepsis
Project no. 5 · Status: Kapanmış · 2015
Summary
Sepsis, defined as a systemic inflammatory response to the infectious disease, was associated with high mortality when complicated with shock and multiorgan system insufficiency despite treatment. In the study, 25 male Sprague-Dawley male rats weighing 250gr were divided into 3 groups. Group 1: Sepsis Group: (n = 10) Perforated with 20 gauge needle, Group 2: Severe Sepsis Group: (n = 10) Cecal incision, Group 3: Sham Group: (n = 5) After laparotomy, graft perforation and manual irritation of intestine and cecum without incision. CRP, PCT, leucocyte and lactate levels were measured at the beginning of study (0. hour) and 6. hour in all groups of rats. A significant increase was detected in PCT levels between 0. and 6. hours in all three groups. Leukocyte and CRP increase was only found in sepsis and severe sepsis groups. No significant changes were detected in lactate levels in 0. and 6. hours in all three groups. We found that increases in PCT, CRP and leukocyte levels in our study were significant in sepsis and were important in early diagnosis and treatment. Key words: Sepsis, inflammatory markers, CRP, PCT, lactate, leukocyte