THE EVALUATION OF POSSIBLE THERAPY EFFECTS OF LYCOPENE WITH HISTOLOGICAL AND BIOCHEMICAL PARAMETERS IN THE EXPERIMENTAL INTRAINAL ADHESION MODEL CREATED IN THE RAT.
Project no. 120 · Status: Kapanmış · 2017
Summary
Objective Peritoneal adhesions are an important clinical problem that occurs after many abdominal surgical interventions, especially gynecological operations. Purpose of the study; to demonstrate the effects of lycopene on the prevention of intraabdominal adhesions in rats with biochemical, histological and macroscopic parameters. Material methods Twenty eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion+corn oil), Group 3 (adhesion+ 5 mg/kg lycopene), Group 4 ( adhesion+20 mg / kg lycopene). Macroscopic adhesion score, histopathological examination, VEGF H-score malondialdehyde (MDA), total anioxidant capacity (TAC) and VEGF values were measured in the groups. Results A statistically significant decrease was found in all adhesion scores in rats given lycopene compared to groups not given lycopene regardless of dose. There were significantly higher extend (P < 0.05), severity (P < 0.05), degree (P < 0.05) and total adhesion (P < 0.05) scores in the CG and CoG than in the LLG and HLG. When histopathological findings are evaluated; inflammation and edema decreased statistically significantly (p <0.05) in the HLG group compared to the other groups. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When LLG and HLG were compared in terms of anti VEGF H-score, no significant difference was observed. MDA levels were statistically significantly lower in the CG and HLG (p<0.05). Conclusion Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation. Key words: adhesion, lycopene, peritoneum, VEGF