Investigation of Human Herpes Virus Type 6 And Type 7 Infection Frequency in Febrile Seizures
Project no. 152 · Status: Kapanmış · 2018
Summary
Abstract Febrile convulsions are the most common type of seizure under the age of five. About 5-8% of all febrile convulsions last longer than 30 minutes and named febrile status epilepticus (FSE). FSE increases the risk of developing epilepsy. Human Herpes virus -6 and Human herpesvirus -7 infection have been shown in several studies to increase the risk of developing FSE . There are no published studies investigating the frequency of human herpes virus- 6 and 7 infections in febrile convulsions in Turkey. In this study; we aimed to determine the frequency of human herpes virus-6 and 7 infections in patients brought to the emergency clinic due to febrile convulsions and to define their relationship with clinical features. 109 patients who were brought to Ege University Children's Hospital due to febrile convulsions and without congenital or acquired immune deficiency were included in the study. Human herpes virus -6 (HHV-6) and human herpes virus -7 (HHV-7) presence were investigated in the plasma samples taken from participants by multiplex PCR (The selected PCR kit, also enabled us to study human parvovirus B19 and enterovirus in addition to HHV-6 and 7. Other infectious agents detected were also presented in the study. 81 patients were brought with simple febrile convulsions, 22 patients with complex febrile convulsions and six patients with febrile status epilepticus. 103 patients had generalized seizures and six patients had focal seizures. The most common seizure type was tonic- clonic seizures (68 patients, 62.38. Four patients were positive for HHV-6 (3.67%), eight patients were positive for HHV-7 (7.34%) and 14 patients were positive for enterovirus (12.84%). No infectious agent was detected in PCR in 83 patients (76.15%). Parvovirus B19 was not detected in any of the patients. 75% of patients who were positive for HHV-6 had simple febrile convulsion and 25% had febrile status epilepticus. 87.5% of patients positive for HHV-7, had simple febrile seizures, 12.5% had febrile status epilepticus. 64.3% of patients positive for had simple febrile seizures, 28.6% had complex febrile convulsions, and 7.1% were presented with febrile status epilepticus. 74.7% of patients with negative PCR results presented with simple febrile convulsions, 21.69% had complex febrile convulsions and 3.61% had febrile status epilepticus. There was no statistically significant difference between the groups in terms of febrile convulsion type (p = 0.28). In this study, HHV-6 positivity was found to be 3.67% in patients brought by febrile convulsions. HHV-7 positivity and enterovirus positivity were 7.34% and 12.84% respectively. There was no statistically significant relationship between the infectious agent and type of febrile convulsion.