CLINICOPATHOLOGICAL CORRELATION OF ERG and PTEN EXPRESSIONS IN BENIGN, PRECURSOR and MALIGN EPITHLEAL PROLIFERATIONS OF PROSTATE
Project no. 140 · Status: Kapanmış · 2018
Summary
OBJECTIVE: Prostate cancer is a clinically and molecularly heterogeneous cancer type with different clinical course and a wide range of treatments. Especially "prostatic intraepithelial neoplasia" (PIN), "atypical intraductal proliferation" (AIP) and "intraductal carcinoma" (IDC) are diagnoses that create difficulty in differential diagnosis in terms of having similar morphological features, and they are entities with different patient treatment and follow-up. In our study, we aimed to determine the expression levels of ERG and PTEN in these lesions and to investigate the prognostic and diagnostic value of these biomarkers. METHODS AND RESULTS: Eighty six cases diagnosed as “Adenocarcinoma” in radical prostatectomy or needle biopsy materials in the Department of Medical Pathology of EUTF in 2011-2012 were included in the study. IDC was determined in 6 of the cases, AIP in 29 and PIN in 52 cases. IDC and AIP were more common in tumors with DG 3 and above. Prostate carcinomas accompanied by IDC and AIP had a shorter survival time (p=0.043). In tumors containing IDC and AIP, ERG and PTEN status were consistent with the invasive component. In addition, ERG was positive in all IDC areas. Heterogeneous staining was observed with PTEN, and PTEN was more negative in the areas of invasive carcinoma and IDC (p=0.63). Although ERG positivity and PTEN negativity were not statistically significant, it was noted that they supported the diagnosis of AIP. CONCLUSİONS: Especially in intraductal lesions that cause differential diagnosis, ERG positivity and PTEN negativity should not be ignored in biopsies that may accompany clinically important prostate carcinoma, and the patient should be followed up with treatment accordingly. Keywords: atypical intraductal proliferation, ERG, intraductal carcinoma of the prostate, prostate adenocarcinoma, PTEN