Effects of Black Mulberry Syrup and Hyaluronic Acid on Prevention of Oral Mucositis in Patients Receiving Chemotherapy After Surgery
Project no. 815 · Status: Kapanmış · 2018
Summary
This study is a randomized, controlled experimental study designed to evaluate the efficacy of black mulberry syrup and hyaluronic acid (Gelclair) in the prevention of CT-induced OM (5-Florourosil) in patients undergoing surgery for the diagnosis of gastrointestinal cancer. Before study, permission was received. Financial support was provided by Ege University Scientific Research Projects (BAP) Coordinator. The research was performed in a chemotherapy unit and oncology service of a Training and Research Hospital in Muğla on 22 January-29 August. Power analysis was made in order to determine the number of patients. Black mulberry syrup were administered (36 patients) to the first group; hyaluronic acid (Gelclair) were administered (36 patients) to the second group, and the standard protocol of the clinic were administered (34 patients) to the third group. The data is structured questionnaire including socio-demographic and disease characteristics of the individuals, WHO's mucositis staging scale, WHO Quality of Life in Patients with Oropharyngeal Mucositis (QMQoL) and the satisfaction of the patients with the solutions to evaluate satisfaction. collected with. The patients were evaluated by the observer on the 7th and 14th and 21st days by the researcher and the scores of mucositis staging and quality of life scale were recorded. Frequency and mean ± standard deviation, Chi-square analysis, Kruskal Wallis and Bonferroni paired comparison tests were used to evaluate the data. Stage 3 and 4 mucositis were not observed in all groups on days Stage 3 and 4 mucositis were not found in the three groups on the 7th, 14th and 21st days. On the 7th day, there was a significant relationship in relation to Stage 0, 1, and 2, only group 1 mucositis developed in Group 1. On the 14th day; In the third Group, the stage 1 mucositis should be between 8.8%, while this rate was 5.6% in the second group, there was no mucositis in the first group. On day 21, there was a significant relationship between Stage 0, 1 and 2, only Group 1 mucositis developed in Group-1, 32% of Group-3, Stage 1, 22.2% of Group-2 and Stage 1 mucositis developed in 13.9% of group-1. It has been investigated that the use of blackberry syrup reduces the frequency and severity of oral mucositis. Key Words; Oral mucositis, Chemotherapy, Black mulberry syrup, Hyaluronic acid.