Evaluation of the relationship between posttraumatic growth development and serotonin transporter gen promotor region polymorphism and psychosocial factors in patients with breast and gynecological cancer.
Project no. 20894 · Status: Kapanmış (Yayın bekleniyor) · 2019
Summary
INTRODUCTION : On the other hand recent studies have shown that, after getting cancer diagnosis, some individuals enter into a period which is called “posttraumatic growth” that includes positive changes in their self-perception, interpersonal relationships, and psychological development. Serotonin polymorphism was found effective in the regulation of behaviors and many psychiatric diseases. The aim of this study is to investigate the relationship between SERT gene promoter region polymorphism and posttraumatic growth in patients with newly diagnosed breast cancer and gynecological cancer. METHOD: Patients with newly diagnosed breast cancer or gynecological cancer between 18-65 years of age were included in the study The scales were applied by interviewing the patients three times in quarterly periods. In the first assessment, a blood sample was taken from the patients, and serotonin transporter gene promoter region polymorphism, which was shown to be associated with psychiatric disorders, was investigated. The relationship between this polymorphism and posttraumatic growth was examined.During this project, support was received from Ege University Scientific Research Projects Coordination Unit, with the project code TGA-2019-20894, within the scope of the General Research Project, in order to meet the budget of the genetic materials and kits required for the study of serotonin transporter gene promoter region polymorphism. RESULTS: No significant relationship is found between posttraumatic growth and genetic polymophism. Psychological Resilence scores are found to be statistically higher in the patients who developed posttraumatic growth than the patients who did not develop posttraumatic growth (p = 0.0412). DISCUSSION AND CONCLUSION: The number of 128 samples that we determined in the initial targets of our study could not be reached due to the Covid Pandemic and the sensitivity of oncological patients, especially in this process. Due to the current limitations, the study was completed with 73 samples. It is considered to make a contribution to the literature by being the first study to investigate the relationship between posttraumatic growth and genotype and considered to be a prospective study in the literature with including detailed psychiatric variables Key words: Depression, cancer, mental adjustment to cancer, psychological resilience, serotonin transporter gene promotor region polymorphism, posttraumatic growth, posttraumatic stress disorder