ROLE OF PD-1 MARKER IN DIAGNOSTIC ALGORITHM OF MYCOSIS FUNGOIDES PATIENTS
Project no. 21638 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
Mycosis fungoides (MF) is the most prevalent cutaneous T cell lymphoma. Clinically it follows patch, plaque and tumoral stages. Early stage MF can mimic inflammatory dermatoses such as psoriasis vulgaris, lichen planus, dermatitis and parapsoriasis group diseases. Programmed Death-(PD-1) is an immunoglobulin superfamily transmembrane glycoprotein and after binding to PDL-1 and PDL-2, it diminishes T cell receptor signaling by inhibiting CD28-CD80 pathway. It is thought that this repression of T cell functions may play a role in escape of neoplastic cells from immune system. In this study, it was aimed to evaluate value of PD-1 in MF diagnosis and in discriminating MF from inflammatory dermatoses. Also, if statistically meaningful positivity found to be present in MF group compared to other groups, this positivity was aimed to be compared within clinical, TNMB stages and histopathologic subtypes in MF group. There were 44 MF patients in first group; 30 inflammatory dermatosis patients in second group with diagnoses such as psoriasis vulgaris, lichen planus and dermatitis and 30 patients in third group consisting of 21 parapsoriasis, pityriasis lichenoides chronica group patients and 9 patients who did not have histopathological MF diagnosis but still had suspicious clinical MF findings. Relevant biopsies were examined with anti-PD-1 monoclonal antibody by immunohistochemistry. Both positive staining rate and degree of statining positivity were stastically higher in MF group compared to inflammatory group and third group. PD-1 positivity was also higher in advanced stage MF patients and transformed MF patients compared to early stage and non-transformed MF patients.