Development of a new radiopharmaceutical kit to be radiolabeled with Lu 177 for use in breast cancer treatment
Project no. 22115 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
<p>Recent developments in cancer treatment; It significantly improves the survival and quality of life of cancer patients. Today, the most important treatment methods for cancer are chemotherapy, surgical intervention and radiotherapy. In recent years, many studies on radioimmunotherapy have been carried out. New drugs and treatment strategies are constantly being researched, and targeted cancer therapy is the treatment method with the highest efficacy and least side effects compared to other methods. Within the scope of his doctoral thesis, to develop new theranostic radiopharmaceuticals to be used in breast cancer treatment by radiolabeling the active substance of TRZ used in immunotherapy targeted to breast cancer tumors with Lu-177. Breast cancer is the most common type of cancer in women. Human epidermal growth factor receptor 2 (HER2) is overexpressed in 20-30% of breast cancer cases. TRZ is a recombinant DNA-based humanized monoclonal antibody targeting the HER2 protein. Radioimmunotherapy is a targeted therapy that has the potential to increase the effectiveness of conventional monoclonal antibodies. Since trastuzamab will be used as a carrier, it will be used in lesser amounts than the treatment dose. Thus, both side effects and cost will be reduced. Lu-177 has been reported to be effective at localizing cytotoxic radiation in relatively small areas, with less damage to surrounding normal tissue, and competent at destroying metastatic lesions as well as small tumors. The Lu-177 also emits gamma rays suitable for dose evaluation and imaging. Radionuclides emitting beta particles are largely targeted to tumor tissues without harming healthy cells with monoclonal antibodies. It is aimed to destroy tumor cells both by the effect of the monoclonal antibody and the effect of the beta particle. Radionuclide – monoclonal antibody radiolabeling, quality control, in vitro stability studies and in vivo imaging studies were carried out within the scope of doctoral thesis.</p>