Efficacy of intrapleural hypochlorous acid lavage in the treatment of empyema in rats
Project no. 21875 · Status: Kapanmış · 2021
Summary
<p>Empyema, which is defined as infection and accumulation of purulent material in the pleural cavity may develop in approximately 1 in every 150 children treated in hospital for pneumonia. It is a pathology that can cause significant morbidity. In addition to parenteral antibiotic therapy, tube thoracostomy for drainage, surgery (by thoracoscopy or thoracotomy) of fibrinous particles deposited in the intrapleural space or enzymatically (with fibrinolytic therapy) debridement, and surgical removal (decortication) of the thick fibrinous layer that prevents lung expansion is applied. At second stage (fibrinopurulent) empyema hospitalization of patients treated with tube drainage and fibrinolytic or thoracoscopic debridement is required. The hospitalization period reaches to 2-3 weeks, this situation affects both psychosocial and psychosocial problems in pediatric patients and their families and cause economic morbidity.</p><p><br></p><p>In this study, hypochlorous acid solution was experimentally used for second stage empyema. Efficacy of administration of hypochlorous acid as intrathoracic lavage in rats has been researched. Within the scope, second stage of empyema was created by intrapleural injection of bacteria in Wistar rats . Two treatment groups (hypochlorous acid and saline groups) were administered consecutively. Treatment with 3 consecutive thoracentesis was applied in three groups whereas lavage was not applied to the control group. Subjects were sacrificed at 48 hours following the last administration of lavage and intrathoracic pleural reactions were macroscopically staged.</p><p><br></p><p>As a result; macroscopically stage 2 empyema development could not be achieved in rats, therefore, efficacy comparisons of hypochlorous acid and saline lavages could not be made. should be treated. The study was terminated due to unsuccesful ampyema model.</p>