The Effect of Anaerobic Exercise on Bone Morphogenetic Protein 9
Project no. 22186 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
<p>Bone Morphogenetic Protein 9 (BMP9) plays a key role in the bone and cartilage remodeling, hence is important in training adaptations, especially in anaerobic exercise. However, little is known about its role of anaerobic exercise. This study evaluated the role of BMP9 on the impact of acute and chronic anaerobic exercise on bone metabolism markers. Post prandial venous blood samples were collected pre- and post- acute YOYO intermittent recovery test (level 1) from and 41 sedentary volunteers (age: 22.3±3.5 years) and 40 trained male athletes (age: 20.7±2.5 years) all participate in anaerobic sports (like volleyball, basketball, and handball). Parameters evaluated were serum BMP9, a marker of bone formation and resorption; C-terminal telopeptide of type1 collagen (CTX1), alkaline phosphatase (ALP), calcium and cartilage oligomeric matrix protein (COMP) levels. Serum BMP9 values of the athlete and control groups after exercise (YOYO test) were higher than before (16.3% and 16.7%, respectively, p>0.05). In addition, pre-exercise (resting) BMP9 values (17.1%) and acute post-exercise values of the athlete group were higher than those of the control group (16.7%). The post-exercise ALP, COMP and CTX1 values of the athletes were higher than the pre-exercise values (p<0.001). The pre- and post-test ALP values of the athlete group were significantly higher than those of the control group (p=0.011 and p=0.013, respectively). Calcium (p=0.033), ALP and COMP (p<0.001) values after exercise were higher in the control group than before exercise. In addition, a significant positive correlation was found between YOYO IR-1 value and COMP values before and after exercise in athletes. A significant negative correlation was found between YOYO endurance level and CTX1 value after exercise in athletes (p<0.01). Between COMP and CTX1 before exercise (r=0.311, p=0.051) and between BMP9 and CTX1 after exercise (r= 0.318 p= 0.046) in athletes; In the control group, positive correlations were found between BMP9 and COMP after exercise (r= 0.440 p=0.004). These findings demonstrate that acute and chronic anaerobic exercise activates bone and cartilage metabolism through BMP9, suggesting that BMP9 may be involved in bone-related anaerobic training adaptations.</p>