Investigation of proliferative and apoptotic effects of some endemic snake venoms on prostate cancer cell lines
Project no. 30838 · Status: Kapanmış (Yayın bekleniyor) · 2023
Summary
<p>This study aims to investigate the proliferative and apoptotic effects of some endemic snake venoms (Macrovipera lebetina obtusa, Montivipera xanthina, Walterinnesia morgani) on prostate cancer cell lines. Prostate cancer is one of the most common cancer types in men. According to US data, it is the second most lethal cancer type in men and the development of new treatment approaches is important. Therefore, discovering potential drug candidates obtained from natural sources is very important in cancer treatment.</p><p>In the study, the cytotoxic venom dose obtained by IC50 determination with WST-1 as a method, the proliferative-apoptotic effect of biomarkers (Ki67, caspase-3, caspase-6, caspase-9, Bcl2, Bax and Annexin V) after application to cultured cancer cell lines (DU145 and PC3) will be determined by immunofluorescence method and the biostatistical evaluation of the data will be presented.</p><p>The venoms to be used will be new and effective in the treatment of prostate cancer, which will be tried for the first time. They have the potential to offer an approach. Snake venoms are of great interest in medical research due to the bioactive components they contain.</p><p>The results of the study may reveal the potential for developing new treatment strategies by illuminating the effects of endemic snake species' venom on prostate cancer cell lines. The data to be obtained will make a significant contribution to identifying a new target for prostate cancer treatment and evaluating the usability of naturally derived compounds. The study aims to contribute to the literature by filling a gap in prostate cancer treatment and to contribute to developing more effective and less side-effect treatment options.</p>