Effect of Fusobacterium nucleatum Amount on Disease Activity in Ulcerative Colitis
Project no. 21827 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
<p>Inflammatory bowel disease (IBD) is a disorder that causes chronic inflammation in the digestive tract. IBD is known as Crohn's disease (CD) and ulcerative colitis (UC). The exact causes of the disease are not known, but it is known that factors such as genetic predisposition, smoking, and irregular microbiota play a role in the development of IBD. IBD has been increasing worldwide in recent years.</p><p>The origin of IBD is due to interactions of genetic and environmental factors, dysregulation of immune system responses, and changes in the gut microbiome. UC is characterized by persistent mucosal inflammation of the colon; CH can affect any region in the gastrointestinal tract.</p><p>Many medications are used in the treatment of IBD. Anti-TNF agents are effective in reducing inflammation in patients with IBD. TNF-α has an important role in the pathogenesis of IBD. Anti-TNF therapy may be effective in patients with IBD.</p><p>The human gut microbiota has a fundamental role in the pathogenesis of IBD. In cases of IBD, imbalances in the microbiota and a decrease in biodiversity are observed. F. nucleatum is commonly found in the mouth and intestine. This bacterium may be involved in the development of IBD. The F. nucleatum strain can invade the colon by adhering to the colon epithelium and increase TNF-α cytokine expression.</p><p>The study investigates the relationship and disease activity between IBD and F. nucleatum. In addition, the importance of the TNF factor of F. nucleatum, which is associated with UC, in the course of the disease is examined. Findings showed that F. nucleatum density increased in patients. Treatment approaches targeting F. nucleatum and TNF-α may reduce UC symptoms and halt disease progression. Therefore, investigating F. nucleatum and related pathways is important for more effective treatment of UC.</p>