Evaluation of Serum Sirtuin 1 and Sirtuin 6 Levels in Pediatric Patients with Nephrotic Syndrome

Project no. 27404 · Status: Kapanmış (Yayın bekleniyor) · 2023

Summary

INTRODUCTION: Nephrotic syndrome (NS), a common pediatric kidney disease, is characterized by massive proteinuria, hypoalbuminemia, and edema due to increased protein permeability in the glomerular filtration barrier. Sirtuins (SIRT1–SIRT7) are NAD-dependent protein deacetylases regulating cellular processes. SIRT1 and SIRT6 stabilize the podocyte actin cytoskeleton, reduce podocyte injury, and proteinuria, making them potential therapeutic targets. This study aimed to compare serum SIRT1 and SIRT6 levels in children with NS and a healthy control group.MATERIALS AND METHODS: The study included children diagnosed with NS or proteinuria at Ege University Faculty of Medicine, excluding those with infections, chronic diseases, or medication use.RESULTS: The study analyzed 51 patients and 37 healthy controls. Median age was 141 [41–245] months. Median SIRT1 levels were 0.1294 [0.0996–2.0137] in patients and 0.1313 [0.1021–0.2590] in controls (p=0.398). Median SIRT6 levels were 0.3140 [0.1560–3.1640] in patients and 0.3640 [0.1592–2.8790] in controls (p=0.293). In the NS subgroup, SIRT1 levels were 0.1334 [0.1071–2.0137] versus 0.1249 [0.0966–0.3871] (p=0.466). While SIRT1 levels were similar across proteinuria groups (p=0.984), SIRT6 levels differed significantly (p=0.002).CONCLUSION: The lack of significant differences in SIRT1 and SIRT6 levels may relate to the pediatric population and short disease exposure. The lower SIRT6 levels in severe proteinuria cases suggest early involvement. Larger studies with longer disease durations are needed.Keywords: Nephrotic syndrome, Sirtuin1, Sirtuin6, podocyte, Childhood

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