Investigation of the association betweeen disease and internal dose levels of environmental pollutants
Project no. 393 · Status: Kapanmış · 2014
Summary
This study aimed at exploring whether there is an association between environmental exposure to persistent organic pollutants (POPs) and stomach tumor progression, as well as whether blood POP concentration reflect internal POP concentrations. While the first is intended to understand if concentrations of POPs have a role in primary tumor development in stomach tissue, second is intended to understand if concentrations of POPs in blood, the more easily accessed biological specimen compared to inner organs, can be used as biomarker for total body burden of POPs. Our results showed that the concentrations of 4 members of POPs in omentum of stomach cancer patients are significantly higher than the concentrations of POPs in omentum of control patients. For the second aim, positive correlations between some blood and omentum POP concentrations were observed with the strongest values of organochlorinated pesticides (OCPs) and of polychlorinated biphenyls (PCBs). However, there were no correlations for the last analyzed POP groups, polybrominated bipheyl ethers (PBDEs) between blood and omentum concentrations.