Investigation of Anticancer Effect and Mechanism of Extracts from the Aerial Parts of Salvia tomentosa Mill. on Different Cancer Cell Lines
Project no. 29657 · Status: Kapanmış · 2023
Summary
<p>Cancer is one of the leading causes of death worldwide. The incidence of cancer is predicted to continue to rise due to increased exposure to environmental carcinogens. Surgical treatment, radiation therapy and chemotherapy, alone or in combination, are used to treat cancer. However, since chemotherapy and radiotherapy cause acute side effects in patients, research is being conducted to develop drugs with fewer side effects. The World Health Organization reports that more than 80% of people in developing countries use natural products for treatment. Today, about 60% of anticancer agents are derived from plants and the use of natural products for anticancer drug development is of great scientific and commercial interest. The family Lamiaceae, to which Salvia tomentosa belongs, includes plants with essential oils used in medicine, food, cosmetics and pharmaceutical industries. In the literature, it has been reported that extracts from Salvia species and molecule groups isolated from these extracts have antibacterial, antioxidant, antitumoral and anti-inflammatory activities. For this reason, Salvia species are of great importance as potential targets for drug development. There are limited number of studies investigating the anticancer effect of Salvia tomentosa.</p><p>For this purpose, it is aimed to determine the anticancer effects of different polarity extracts obtained from the aerial parts of S. tomentosa by examining 1) proliferation rate 2) apoptotic death levels 3) the migration levels on MCF-7, PC-3, UPCI-SCC-131, Huh-7 and A7r5 cells. Thus, within the scope of the project proposal, the possible anti-cancer effects of extracts of different polarity obtained from the above-ground parts of S. Tomentosa, which is naturally distributed in our country, on MCF-7, PC-3, UPCI-SCC-131, Huh-7 and A7r5 cells will be investigated for the first time in the literature. Most of the studies will be carried out using the infrastructure of the Department of Pharmaceutical Botany, Department of Pharmacology and Pharmaceutical Sciences Research Laboratory.</p>