Evaluation of usability of serum oxidative stress related biomarkers as prognostic factors in primary open angle glaucoma suspects
Project no. 23429 · Status: Kapanmış · 2022
Summary
<p><strong><em>Purpose:</em> </strong>To evaluate the serum levels of oxidative stress related molecules in patients with ocular hypertension (OHT) and primary open angle glaucoma (POAG) and compare with healthy controls (HCs).</p><p><strong><em>Materials and Methods:</em> </strong>Treatment naive patients with no known systemic diseases and with OHT<strong> </strong>and POAG diagnosis were included. Age and gender matched healthy volunteers with no ocular and systemic diseases were included as HCs. None of the participants were under any topical or systemic treatment or vitamin/antioxidant supplements. Smokers were excluded. Serum levels of total antioxidant capacity (TAC), ascorbic acid, protein carbonyls(PCs), advanced glycation end products(AGEs), neuronal pentraxin 2(NPTX-2) and beta amyloid precursor protein(Aβ) were analyzed.</p><p><strong><em>Results:</em> </strong>A total of 90 patients (30 in each group) were included in the study. Groups were similar in terms of age and gender distribution. Serum levels of TAC (1.47±0.11 mmole/L) was significantly higher in OHT, compared to HCs(1.40±0.11 mmole/L) and POAG(1.30±0.08 mmole/L) (p<0.05). No significant difference was detected in serum levels of ascorbic acid, PCs and AGEs.</p><p><strong><em>Conclusion:</em> </strong>Serum levels of TAC were significantly higher in OHT patients, and this might have a role in protection of the optic nerve despite increased intraocular pressure.<strong> </strong></p>