Investigation of the Interactions of Phenolic Acid Derivatives with Model Membranes at Molecular Level with Spectroscopic and Calorimetric Techniques
Project no. 23587 · Status: Kapanmış (Yayın bekleniyor) · 2022
Summary
<p>Phenolic acids are one of the main groups of plant secondary metabolites with structural diversity. They are bioactive natural antioxidants and are believed to have therapeutic effects against various chronic diseases. Studying the interactions of phenolic acids with biomolecules such as phospholipids is of great importance for understanding their effects on the structural and dynamic properties of cellular membranes. Moreover, a simplified membrane model system that mimics a cellular environment has always been useful in molecular interaction-based studies to avoid the structural complexity of biological membranes. Although phenolic acids are natural potential drug agents and can be found easily, the number of studies examining their molecular interactions with lipid membranes, which is one of the main building blocks of a cell, is very few. In this thesis, the interactions of phenolic acids such as syringic acid (SA), ferulic acid (FA) and tyrosol with dipalmitoyl phosphatidylcholine (DPPC) membranes, respectively, as representatives of hydroxybenzoic, hydroxycinnamic and hydroxyphenyl acetic acid groups, were investigated using FTIR and DSC techniques. The effects of these compounds on membrane order and fluidity (dynamics) depending on temperature and concentration, as well as changes in thermodynamic parameters such as phase transition temperature, enthalpy and width at half height were investigated. The aim of this study is to contribute to the understanding of the cellular and molecular mechanisms responsible for the potential therapeutic activities of these compounds against various diseases.</p>