THE IMPORTANCE OF STREM AND PRESEPSIN IN THE DIAGNOSIS AND MONITORING OF FEBRILE NEUTROPENIA IN THE PEDIATRIC AGE GROUP.
Project no. 32560 · Status: Kapanmış (Yayın bekleniyor) · 2024
Summary
<p>Febrile neutropenia is defined as a body temperature of 38 degrees Celsius or higher, or a temperature of 38 degrees Celsius or higher lasting longer than 1 hour, with an absolute neutrophil count (ANS) of 500 cells/microliter or less, or a decrease in the absolute neutrophil count to 500 cells/microliter within the following 24 hours. Febrile neutropenia is a significant cause of mortality and morbidity, particularly in patients diagnosed with hematological malignancies. Prolonged hospital stay, chemotherapeutic drugs, and long-term antibiotic treatment increase this risk. Bacterial infections can be responsible for febrile neutropenia; therefore, early biomarkers may be necessary for rapid antibiotic treatment. This study will evaluate the significance of presepsin and sTREM levels in diagnosis and prognosis, and their success in demonstrating bacterial infection, in febrile neutropenic patients admitted to Ege University Children's Hospital, both at admission and 48 hours after fever-free status. This will enable the prediction of the prognosis of patients presenting with febrile neutropenia and will identify patients who need early antibiotic therapy and those who do not. This will prevent patients with suspected bacterial infections from receiving unnecessary antibiotic treatment and will ensure that antibiotic therapy is initiated early in patients who do require it.</p><p>Send feedback</p>