PRİMER SJÖGREN SENDROMLU HASTALARDA PERİODONTAL HASTALIĞA BAĞLI GELİŞEN ENFLAMASYONUN LOKAL VE SİSTEMİK ETKİLERİNİN ARAŞTIRILMASI
Project no. 377 · Status: Kapanmış · 2017
Summary
Aim: The aim of the present study is to compare the clinical periodontal findings as well as gingival crevicular fluid (GCF) and plasma levels of tumornecrosis factor-alpha (TNF-??), interleukin-1beta (IL-1??), interferon gamma (IFN-??) and caspase-1 in primary Sjögren syndrome (pSS) and rheumatoid arthritis (RA) subjects. Methods: In the present case control study plasma and GCF samples were collected,full-mouth recordings comprising plaque index (PI), bleeding on probing (BOP) and probing depth (PD) were performed in 44 subjects with pSS, 39 subjects with RA and 30 systemically healthy subjects. Plasma and GCF TNF-??, IL-1??, IFN-gamma and caspase-1 levels were determined by enzyme-linked immunosorbent assay. Results: There were no differences in GCF and plasma levels of IFN-??and TNF-?? in all the study groups (p>0.05). GCF levels of IL-1?? were higher in pSS group than healthy group (p=0.035). Caspase-1 GCF levels were significantly higher in pSS group than RA group (p=0.032). Highest plasma IL-1?? levels were detected in pSS compared to RA and healthy groups (p<0.001). Healthy group has higher caspase-1 plasma levels than pSS and RA groups (p<0.001). Saliva levels of TNF-?? and caspase-1 were significantly higher in pSS versus control group (p<0.001). Conclusions: The results of the present study reveal that the periodontal status of patients with pSS does not differ from systemically healthy subjects. Further studies involving longitudinal assessments on larger populations with standardized patient inclusion criteria are needed to confirm the findings.