Development of Chitosan-Silk Protein-Based Hydrogel Systems for Use in Neurological Tissue Engineering

Project no. 33079 · Status: Kapanmış · 2025

Summary

<p>In&nbsp;this&nbsp;study,&nbsp;the&nbsp;development&nbsp;and&nbsp;characterization&nbsp;of&nbsp;crosslinked&nbsp;hydrogel&nbsp;systems&nbsp;for&nbsp;biomedical&nbsp;applications&nbsp;were&nbsp;aimed.&nbsp;Hydrogels&nbsp;are&nbsp;considered&nbsp;important&nbsp;biomaterials&nbsp;in&nbsp;tissue&nbsp;engineering&nbsp;and&nbsp;controlled&nbsp;drug&nbsp;delivery&nbsp;systems&nbsp;due&nbsp;to&nbsp;their&nbsp;high&nbsp;water&nbsp;retention&nbsp;capacity,&nbsp;biocompatibility,&nbsp;and&nbsp;tunable&nbsp;physicochemical&nbsp;properties.</p><p>Within&nbsp;the&nbsp;scope&nbsp;of&nbsp;the&nbsp;study,&nbsp;different&nbsp;hydrogel&nbsp;formulations&nbsp;composed&nbsp;of&nbsp;natural&nbsp;and&nbsp;synthetic&nbsp;polymers&nbsp;were&nbsp;prepared,&nbsp;and&nbsp;three-dimensional&nbsp;polymeric&nbsp;network&nbsp;structures&nbsp;were&nbsp;formed&nbsp;using&nbsp;various&nbsp;crosslinking&nbsp;strategies.&nbsp;The&nbsp;swelling&nbsp;behavior,&nbsp;mechanical&nbsp;properties,&nbsp;viscoelastic&nbsp;characteristics,&nbsp;and&nbsp;structural&nbsp;stability&nbsp;of&nbsp;the&nbsp;prepared&nbsp;systems&nbsp;were&nbsp;evaluated.&nbsp;In&nbsp;addition,&nbsp;the&nbsp;effects&nbsp;of&nbsp;crosslinker&nbsp;concentration&nbsp;and&nbsp;polymer&nbsp;composition&nbsp;on&nbsp;hydrogel&nbsp;performance&nbsp;were&nbsp;investigated.</p><p>The&nbsp;obtained&nbsp;results&nbsp;demonstrated&nbsp;that&nbsp;increasing&nbsp;the&nbsp;crosslinking&nbsp;density&nbsp;resulted&nbsp;in&nbsp;a&nbsp;more&nbsp;compact&nbsp;hydrogel&nbsp;network&nbsp;structure,&nbsp;enhanced&nbsp;mechanical&nbsp;strength,&nbsp;and&nbsp;altered&nbsp;swelling&nbsp;behavior.&nbsp;Consequently,&nbsp;the&nbsp;developed&nbsp;hydrogel&nbsp;systems&nbsp;were&nbsp;found&nbsp;to&nbsp;be&nbsp;promising&nbsp;biomaterials&nbsp;for&nbsp;controlled&nbsp;drug&nbsp;delivery&nbsp;and&nbsp;tissue&nbsp;engineering&nbsp;applications.</p>

View details