Arterial stiffness parameteres change before and after hysterectomy and bilateral salpingooophorectomy in patients with sexual identity disorder (Female to Male)
Project no. 21781 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
<p>In epidemiological studies, the incidence of cardiovascular diseases has been shown to be higher in male gender. Testosterone is one of the important risk factors in the fact that cardiovascular mortality in men is 5 times higher than in healthy women with normal menstruation. The direct effects of androgens that occur through receptors in vascular structures lead to many vascular structural and functional changes. Many tests can be done to identify these changes in the early period. Carotid intima-media thickness (CIMK) and flow-mediated vasodilation (AAVD) testing, measured noninvasively (by ultrasound), are considered to be indicators of atherosclerosis and endothelial function, respectively. On the other hand, arterial stiffness parameters, which are important indicators of vascular health, have been shown in many studies to play a predictive role in the development of vascular damage and atherosclerotic cardiovascular diseases. Carotid-femoral pulse wave velocity (NDH), an important independent factor for cardiovascular diseases, has been accepted as the gold standard for measuring arterial stiffness. In this project, patients who were diagnosed with sexual identity disorder and routinely received androgen replacement therapy, who were hospitalized in the Gynecology and Obstetrics Clinic for hysterectomy and bilateral salpingo-oophorectomy operation, measured local carotid artery stiffness parameters, which are an indicator of arterial stiffness, at 1 month and 3 months before and after the operation, and the estrogen source was completely determined. It was aimed to determine the changes of stiffness parameters at 1 and 3 months after removal. It was aimed to take age-matched healthy female gender group and healthy male gender group as the control group.</p>