THE ROLE OF HYDROGEN SULFIDE (H2S) IN THE VASOCONSTRICTIVE EFFECTS OF SEROTONIN (5HT)
Project no. 21428 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
<p>H2S is a gasotransmitter whose physiological and pathophysiological importance has been discovered in recent years. H2S has tissue-specific effects on vascular tone. While there are many studies on the effects of H2S on relaxation, there are not enough studies on its effects on contraction. On the other hand, serotonin (5-HT) is an important mediator in the cardiovascular system. It has been shown that contraction mechanisms and sensitivity associated with 5-HT change in diseases such as atherosclerosis and hypertension, and 5-HT is involved in the mechanism of vascular dysfunction. Interestingly, studies have been reported showing that 5HT increases H2S in aortic smooth muscle cells and in an oyster species. However, there is no study yet to show whether the vasoconstrictor effects of 5HT are mediated by H2S.</p><p>In addition, symptoms occur as a result of vasodilation of intracranial vessels during migraine attacks and acute</p><p>The use of 5HT1B/1D receptor agonists in migraine attacks reduces migraine symptoms through vasoconstriction.</p><p>alleviates. H2S has also been shown to have vasoconstrictor effects on cerebral arteries. However, it is not known whether 5HT stimulates the formation of H2S in the brain. For this reason, we aimed to elucidate the relationship between 5-HT-H2S by investigating the role of H2S in the vasoconstrictor responses of 5-HT in the aorta and the effects of 5-HT on H2S synthesis in the aorta and brain. For this purpose; effects on H2S formation will be investigated by methylene blue method, effects on vascular tone in the aorta by myograph experiments in the presence/absence of H2S synthesis inhibitor.</p>