Effect of taurine on rat Achilles tendon healing
Makaleler > Tam Makale · 2015
Yazarlar: Ovunc Akdemir, William C. Lineaweaver, Turker Cavusoglu, Erdal BİNBOĞA, Yiğit UYANIKGİL, Feng Zhang, Feng Zhang, Feng Zhang, Mahmut PEKEDİS, Tugay Yagci
CONNECTIVE TISSUE RESEARCH, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2015, cilt 56, ss 300-306
DOI: 10.3109/03008207.2015.1026437
Özet
Taurine has anti-inflammatory and antioxidant characteristics. We have introduced taurine into a tendon-healing model to evaluate its effects on tendon healing and adhesion formation. Two groups of 16 rats underwent diversion and repair of the Achilles tendon. One group received a taurine injection (200mg/ml) at the repair site, while the other group received 1ml of saline. Specimens were harvested at 6 weeks and underwent biomechanical and histological evaluation. No tendon ruptured. Average maximum load was significantly greater in the taurine-applied group compared with the control group (p<0.05). Similarly, average energy uptake was significantly higher in the taurine-applied group compared with the control group (p<0.05). We observed no significant differences in stiffness in both groups (p>0.05). After histological assessment, we found that fibroblast proliferation, edema, and inflammation statistically decreased in the treatment group (p<0.05). These findings could indicate greater tendon strength with less adhesion formation, and taurine may have an effect on adhesion formation.