Response With Methylphenidate to ADHD-Like Symptoms in Pervasive Developmental Disorder: Does CES-1 Enzyme Gene Polymorphism Have a Role?
Makaleler > Tam Makale · 2016
Yazarlar: Ulku AKYOL ARDIC, Eyüp Sabri ERCAN, Duygu Döndü AYGÜNEŞ JAFARI, DENİZ YÜCE, Sibel DURAK, Buket KOSOVA
TURK PSIKIYATRI DERGISI, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2016, cilt 28, ss 89-94
DOI: 10.5080/u14883
Özet
Objective: Methylphenidate is the first-choice medication for the Pervasive Developmental Disorders (PDDs), and comorbid Attention Deficit Hyperactivity Disorder (ADHD). But this approach generally results with poor outcomes, and increased adverse effects. It is aimed to investigate the comparison of cases who diagnosed with PDDs and Mild Mental Retardation (MR) and cases with pure ADHD in terms of the clinical response to MPH. Also we aimed to investigate the relations between CES-1 polymorphism gene and the clinical response to MPH.