SP915THE LONG TERM OUTLOOK TO FINAL OUTCOME AND STEROID TREATMENT RESULTS IN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME
Bildiriler > Özet Bildiri
Yazarlar: Nida Dinçel, Ebru Yılmaz, S¸ükriye Hacıkara, I˙pek Kaplan Bulut, Sevgi Mir
Nephrology Dialysis Transplantation, , , Uluslararası, Özet Bildiri, Wos, cilt 30, ss iii678-iii678
Özet
Introduction and Aims: Idiopathic Nephrotic Syndrome (INS) was defined as combination of a nephrotic syndrome and non- specific histological abnormalities of the kidney. Among these abnormalities, minimal change nephrotic syndrome (MCNS) is most common. Aim: we report our experience with MCNS; its clinical course, treatments and outcomes Methods: 120 children (66 male, 54 female) with MCNS, admitted to Nephrology Department of Ege University Children Hospital, Izmir, between1987-2009 were assessed. Their clinical presentations, treatment, and disease courses were reviewed. Results: The mean duration of follow-up was 11.5±1.9 years. Initially, all patients given prednisone 2mg/kg/ day single dose per 4 weeks a followed by 8 weeks of the same daily dose given every other day. After week 12, prednisone was progressively tapered off at the rate of 0.5mg/kg per 15 daily intervals until complete discontinuation had been achieved by week 16. Steroid resistance was accepted as no achievement of remission following 4 weeks of prednisone 2mg/kg/day followed by three intravenous pulses of corticosteroids. At the end of the initial steroid treatment, 106 (88.3%) patients were determinate steroid responsive while 14 (11.7%) patients were steroid resistance. 38 patients underwent biopsy. At the end of study recovery rate was increased from 88.3% to 94.1%.