Current Updates of Epigenetics Interactions For Gained Chemotherapeutic Resistance In Acute Myeloid Leukemia
Kitapta bölümler > Diğer · 2022
Yazarlar: İLAYDA ALÇITEPE, Burçin KAYMAZ
Health Sciences: Current Researches and New Trends, Diğer, "Vikol publishing" ST Kolesnichenko V.V., B, Uluslararası, 2022, ss 158-172, Karadağ, Cetinje, Montenegro
Özet
<p>No matter how well the chemical and molecular structure of DNA has been resolved, with the advancement of technology, it has begun to be understood that everything is not just DNA. Changes occur in gene expressions in the process that starts from the embryo and lasts until the end of life. These changes have included the concept of "epigenetics" in our lives. With this concept, we are talking about a process that does not cause any change in the base sequence and is often reversible. “Epigenetics” is of great importance in controlling gene regulation, determining the differentiation processes of cells, and also elucidating how cells become carcinogenic. The biological events observed in living organisms regularly occur thanks to the interaction of genetic and epigenetic events. Defects occurring between these two systems to a number of diseases (leukemia, neurodegenerative diseases etc.) is inviting. In this review, epigenetics in which changes in gene expression are 187 examined, cancer treatment and the use of biomarkers for cancer are discussed, and how to find solutions to diseases using epigenetic therapy, and the functions of epigenetic regulations in gaining chemoresistance are emphasized. The effects of the drugs used in epigenetic therapy have also been shown in studies, and the only problem is that the specificity is limited for each patient in this process. Therefore, the limited specificity of drugs used in epigenetic therapy is a limiting factor in studies. In conclusion, in our review, we wanted to emphasize the importance of “epigenetics” in our lives by gathering together the concept of epigenetic and its changes in epigenetic process, the therapies performed, and their effects on AML pathogenesis, which is one of the types of leukemia. </p><p><br></p><p>Keywords: Epigenetics; therapy; leukemia, biomarker</p>