Preserved ratio impaired spirometry and OSA may contribute to cardio-metabolic complications: evidence from the ESADA cohort
Bildiriler > Özet Bildiri
Yazarlar: Izolde Bouloukaki, Paschalis Steiropoulos, Athanasia Pataka, Carolina Lombarti, Johan Verbraecken, Özen KAÇMAZ BAŞOĞLU, Dries Testelmans, Georgia Trakada, Ludger Grote, Mafalda Van Zeller, Maria Bonsignore, Walter Mcnicholas, Sophia Schiza
Clinical and epidemiological respiratory sleep medicine, , , Uluslararası, Özet Bildiri, ss PA5341-PA5341
DOI: 10.1183/13993003.congress-2024.pa5341
Özet
Background: Recent studies show Preserved Ratio Impaired Spirometry (PRISm) to be associated with increased risk for mortality due to respiratory and cardiovascular events. Aims and Objectives: To assess prevalence, risk factors, and clinical implications of PRISm in the European Sleep Apnea Database (ESADA, supported by ERS as Clinical Research Collaboration) cohort. Methods: 7,048 obstructive sleep apnea (OSA) patients (AHI≥5 events/h) diagnosed with PG/PSG and free of acute or chronic respiratory disease underwent pulmonary function tests. Participants with PRISm, defined as FEV1/FVC≥0.7 and FEV1 <80% predicted, were further divided by low FVC into restrictive PRISm (FVC <80%) and non-restrictive PRISm (FVC ≥80%). Multivariate regression analysis examined the effect of both forms of PRISm on OSA severity, arterial blood gases (ABGs) and cardio-metabolic risk, after adjusting for confounders. Results: Among all, 888 (13%) patients had PRISm [549 (8%) non-restrictive PRISm and 339 (5%) restrictive PRISm]. BMI, coronary artery disease, diabetes type 2, indices of OSA severity, and ABGs were independently associated with both forms of PRISm (all p<0.001). Male sex, age and cardiac failure were risk factors for restrictive PRISm, whereas current smoking was associated with non-restrictive PRISm. Conclusion: PRISm was independently associated with anthropometrics, OSA severity, and cardiometabolic comorbidities. Therefore, PRISm could be a potential marker for disease severity and cardiovascular risk classification in OSA. However, further studies are needed to explore whether PRISm has a causal association and prognostic significance in OSA patients.