Cytotoxic and inhibitory effects of 4,4′-dihydroxy chalcone (RVC-588) on proliferation of human leukemic HL-60 cells
Makaleler > Tam Makale · 2002
Yazarlar: Güray SAYDAM, Hikmet Hakan AYDIN, Fahri ŞAHİN, O KUCUKOGLU, E ERCIYAS, E TERZIOGLU, filiz büyükkeçeci, SB OMAY
Leukemia Research, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2002, cilt 27, ss 57-64
DOI: 10.1016/s0145-2126(02)00058-9
Özet
Chalcones have been identified as interesting compounds with cytotoxic and tumor reducing properties. In the present study, the biological activity of synthetic chalcones on, myeloid leukemic. cells was, investigated. Human myeloid HL-60 leukemia cells were exposed to 1-20 muM chemicals for 0-96 h. The viability of the cells was measured using trypan blue dye exclusion method. 4,4'-Dihydroxy chalcone (RVC-588) was selected for further experiments to determine characteristics of cytotoxicity among other compounds.