ELECTROCHEMICAL DNA SENSOR TECHNOLOGY FOR MONITORING OF DRUG–DNA INTERACTIONS
Makaleler > Tam Makale · 2008
Yazarlar: Kadriye Arzum ERDEM GÜRSAN, Hakan KARADENİZ, A. CALISKAN, A. VASEASHTA
Nano, Uluslararası, Wos, 2008, cilt 03, ss 229-232
DOI: 10.1142/s1793292008001064
Özet
The objective of this investigation is to understand the nature and dynamics of binding small molecules to bio-macromolecules using electrochemical methods. The investigation pertaining to the design of site- and conformation-specific reagents provides a rationale for new studies of drug delivery design. Some anticancer drugs and DNA interactions have been undertaken by using a variety of techniques. Determination of interaction between DNA and DNA-targeted molecules would be valuable in the design of molecule-specific electrochemical biosensors for applications in diagnostics, development of drugs for chemotherapy, and as a biotechnological tool for DNA-based point-of-care diagnosis.