131I Labeled Zinc Oxide Nanoparticles: Synthesis, Labeling with 131I and in Vitro Uptake Studies on U87-Mg Cells
Makaleler > Tam Makale · 2015
Yazarlar: Özge KOZGUŞ GÜLDÜ, Volkan Tekin, Perihan Unak, Emin İlker MEDİNE, Fazilet Zümrüt BİBER MÜFTÜLER, Canan Özyurt, Serap EVRAN, Suna Timur
Malecular Imaging and Radionuclide Therapy, Uluslararası, 2015, cilt 24, ss 42-43
Özet
Objective: The impact of tuberculosis (TB) on mortality and morbidity is indisputable worldwide and even more so in countries with a high prevalence of Human Immunodeficiency Virus (HIV) co-infection.The development of a non-invasive diagnostic tool that is capable of early and accurate detection, staging and follow-up evaluation of tuberculosis is crucial in minimizing its devastating effects.We evaluated PET/CT imaging with a novel tracer, 68Ga-citrate,in this setting.Methods: Thirteen patients with tuberculosis were included in this prospective pilot study and were imaged with 68Gacitrate.A diagnosis of TB was reached with bacteriological or histopathology studies (n=8) or based on a combination of clinical data, biochemistry and imaging (n=5).PET images were acquired at 60 minutes (and 120 minutes where possible) and analyzed qualitatively (relative to the liver) and semi-quantitatively (using SUVmax and change in SUVmax).PET findings were also compared to that of CT.Results: All 13 patients demonstrated abnormal tracer accumulation in the lungs or extra-pulmonary or both.68Ga-citrate accumulated in every lung lesion noted on CT in six cases (46%).In seven cases (54%) some of the lung lesions noted on CT were not 68Ga-citrate avid, which is suggestive of non-active tuberculosis lesions.Ten patients (77%) demonstrated extrapulmonary involvement, which included various lymph node groups, skeletal lesions, pleural-, splenic-and gastro-intestinal tract involvement.More extra-pulmonary lesions were detected on PET compared to CT in eight cases (80%).The results of dual-time point imaging varied significantly amongst study participants.Conclusion: Pulmonary and extra-pulmonary tuberculosis lesions demonstrate 68Ga-citrate accumulation; with more extrapulmonary lesions detected on PET compared to CT. 68Ga-citrate PET may also provide a way of distinguishing active from inactive lesions for treatment response evaluation.