The Postoperative Course of Troponin T and NT-proBNP Levels in the Pediatric Population Implanted with the HeartMate 3 Device
Makaleler > Tam Makale · 2026
Yazarlar: Seyma Sebnem On, Zulal Ulger Tutar, Eser DOĞAN, Meral Yilmaz, Burcu Busra Acar, Hakan Kurt, Burcugul Karasulu Beci, Asli Tasdemir, Pınar YAZICI ÖZKAYA, Kubra Cebeci, Hür HASSOY, Erturk Levent, Osman Nuri Tuncer, Çağatay ENGİN, Tahir YAĞDI, Mustafa Ozbaran
ANATOLIAN JOURNAL OF CARDIOLOGY, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2026, cilt 30, ss 448-454
DOI: 10.14744/AnatolJCardiol.2026.5944
Özet
Objective: Cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are key biomarkers reflecting myocardial injury and hemodynamic load in heart failure or after cardiac surgery. However, data on their postoperative course in pediatric HeartMate 3 (HM3) recipients are limited. This retrospective case series of ten pediatric patients aimed to evaluate the clinical significance of postoperative changes in these biomarkers. Methods: This retrospective case series included pediatric patients who underwent left ventricular assist device (LVAD) implantation between 2022 and 2024 at the center. Clinical and laboratorydata were retrospectivelyobtained from medical records. Results: Ten patients with dilated cardiomyopathy(PEDIMACS profiles 1-3) were included. The median preoperative cTnT level was 98.5 [IQR 42.5-236.5] ng/L. Median postopera-tive cTnT levels were 182.6 [IQR 88.3-342.9] ng/L at 1 month, 54.0 [IQR 32.0-92.0] ng/L at 6 months, and 43.2 [IQR 25.8-71.4] ng/L at 12 months. Median B-type natriuretic pep-tide (BNP) levels were 7510 [IQR 5350-10850] ng/L preoperatively, 4122 [IQR 2963-7288] ng/L at 1 month, 853 [IQR 520.3-1426] ng/L at 6 months, and 1041 [IQR 619.8-1524] ng/L at 12 months. The mean intensive care unit (ICU) stay was 24.1 +/- 16.3 days. Troponin lev-els returned to normal by postoperative month 6 in all but 2 patients. Spearman analy-sis showed a significant positive correlation between preoperative cTnT and ICU stay (rho = 0.687, P= .028). Conclusion: In pediatric HM3 recipients, cTnT and NT-proBNP levels reflect postoperative myocardial recovery and may serve as clinically useful indicators associated with inten-sive care duration.