The Impact of Radical Nephrectomy on Local Recurrence and Prognosis in Primary Retroperitoneal Liposarcoma: A Comprehensive Analysis of Oncological and Physiological Outcomes
Makaleler > Tam Makale · 2026
Yazarlar: Berk GÖKTEPE, KAMİL ERÖZKAN, Ebubekir KORUCUK, SAFA VATANSEVER, Tufan GÜMÜŞ, Alper UĞUZ, Cemil ÇALIŞKAN, Osman BOZBIYIK
The Anatolian Journal of General Medical Research, Uluslararası, 2026, cilt 36
DOI: 10.4274/anatoljmed.2026.49091
Özet
Objective: Primary retroperitoneal liposarcoma (RPLS) is a rare and biologically heterogeneous malignancy for which complete macroscopic resection remains the cornerstone of curative treatment.However, the role of en bloc radical nephrectomy in achieving optimal oncological outcomes remains controversial.This study aimed to evaluate the impact of radical nephrectomy on local recurrence, survival outcomes, and postoperative renal function in patients undergoing curative-intent resection for primary RPLS.Methods: A retrospective cohort study was conducted, including patients who underwent complete surgical resection for primary RPLS at a tertiary referral center between January 2011 and January 2024.Patients were categorized according to surgical strategy into those undergoing en bloc nephrectomy and those undergoing kidney-sparing resection.The primary endpoint was local recurrence, while secondary endpoints included disease-free survival (DFS), overall survival (OS), perioperative morbidity, and postoperative renal outcomes, assessed using kidney disease: improving global outcomes 2024 criteria.Results: A total of 21 patients (57.1% female) with a median age of 51 years were included (radical nephrectomy: 6; kidney-sparing surgery: 15).The median tumor size was 27 cm, and the majority of tumors were classified as undifferentiated (57.1%).The nephrectomy group demonstrated a lower rate of local recurrence and a longer median DFS than the kidney-sparing group.Five-year OS was also higher in patients undergoing nephrectomy.Importantly, in the nephrectomy cohort, no patient developed postoperative acute kidney injury, and no major complications were observed.Conclusion: En bloc radical nephrectomy appears to improve local disease control and survival outcomes in selected patients with primary RPLS without compromising renal function.These findings support an aggressive surgical approach when required to achieve adequate oncological margins.