Prevalance of Polypoidal Choroidal Vasculopathy in Eyes With Neovascular Age Related Macular Degeneration Resistant to Intravitreal anti-VEGF Treatment.
Makaleler > Tam Makale · 2022
Yazarlar: Jale Menteş, Mine ESEN BARIŞ
turkish journal of ophthalmology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Emerging Sources Citation Index (ESCI), 2022, cilt 52, ss 338-341
DOI: 10.4274/tjo.galenos.2021.16578
Özet
<p>Purpose: To determine the prevalance of polypoidal choroidal vasculopathy (PCV) in intravitreal anti-vascular endothelial growth factor (anti-VEGF) resistant neovascular age related macular degeneration (nvAMD) cases.</p><p>Materials and Method: The eyes that were diagnosed as active and treatment naive nvAMD in Ege University Ophthalmology Department, Retina Unit in between 2011-2018 and were non-responsive to intravitreal anti-VEGF treatment and indocyanine angiography (ICGA) could be obtained were included in the study. The eyes that had fresh hemorrhage in clinical examination or had subretinal, intraretinal, sub-retina pigment epithelial fluid and had accompanying fluorescein dye leakage in florescein angiography (FA) were defined as active nvAMD. PCV was investigated by ICGA in eyes that had activation findings despite at least 6 consecutive intravitreal anti-VEGF injections and defined as nonresponders. The diagnosis of PCV was decided based on the Everest 2 study criterion.</p><p>Findings: A total of 97 eyes of 88 patients were included in the study. Of 88 patients, 44 (50%) were female, 44 (50%) were male and mean age was 75.9±8.3 (59-93) years. Mean number of anti-VEGF injections until the time of ICGA was 7.3±2.2 (6-15). PCV was detected in 62 (63,9%) eyes in ICGA.</p><p>Result: Prevalance of PCV is quite high amongst the eyes with intravitreal anti-VEGF treatment resistant nvAMD in Turkey (63.9%). PCV investigation with ICGA should be conducted for all nvAMD cases that are non-responsive to intravitreal anti-VEGF treatment, both to enlighten the reason of resistance and to modify the treatment as necessary.</p>