Atorvastatin improves peritoneal sclerosis induced by hypertonic PD solution in rats
Articles > Article · 2005
Authors: Soner DUMAN, Sait ŞEN, Eser YILDIRIM SÖZMEN, DG OREOPOULOS
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, Journal Indexed in SCI Expanded, International, 2005, vol 28, pp 170-176
Summary
Background: Peritoneal sclerosis is a complication of peritoneal dialysis and results in ultrafiltration failure. It is related to chronic peritoneal injury due to dialysis solution content and recurrent peritonitis. Statins have anti-inflammatory properties which may be of value in modulating responses to injury. We evaluated the capacity of atorvastatin to modify peritoneal alterations secondary to hypertonic glucose.