Trauma and Inflammation
Kitapta bölümler > Araştırma Kitabı · 2024
Yazarlar: Anıl Murat ÖZTÜRK, Arman VAHABİ
Turkiye Klinikleri Biomedical - Special Topics: Inflammation and in vitro Diagnostics, Araştırma Kitabı, Türkiye Klinikleri Tıp Bilimleri Dergisi, Tanınmış Ulusal, Ulusal, 2024, ss 123-128, Türkiye, Ankara
Özet
<p>Management of severely injured patients is a complicated process with so many questions that need to be answered. Understanding the immune mechanisms and complex physiological responses to trauma is at utmost importance to provide appropriate and up-to-date care. The organism's immune response to trauma is a balanced interactions of inflammatory and anti-inflammatory mediators which purpose is to eliminate the insult faced by the organism and returning it to its pre-injury state. Initial inflammatory response after a trauma described on two main molecular patterns: Damage associated molecular pattern (DAMP) and pathogen associated molecular pattern (PAMP). These patterns act as “signal 0”. DAMPs are well described inflammatory trigger mediators. In severely traumatized patients, treatment protocols should be made with considerations on described immune responses and their clinical effects. Staged approach with “damage control” philosophy should be treatment of choice according to current published literature.</p>